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Spearman rank correlations amongst log Ki for binding in vitro and in vivo log ED50 parameters on the triad take a look at (A–C). Spearman rank correlations involving log EC50 for efficacy in vitro As well as in vivo log ED50 parameters with the triad take a look at (E–File).four. Ester hydrolysis and oxidative defluorination goods could be val